Neuroscape Lab & Glass Brain

The Neuroscape Lab is a unique environment to create and validate novel neurodiagnostics and neurotherapeutics using newly emerging technology with the primary goal of driving rapid translation of neuroscience to real-world solutions. The Glass Brain visualization is one of the lab's projects.

It is being developed as a core research facility at the UCSF Neuroscience Imaging Center (NIC) under the direction of Dr. Adam Gazzaley.

Precision Biosystems Laboratory – Ga. Tech

Principal Investigator: Craig Forest

The Precision Biosystems Laboratory is focused on fundamental engineering advancements, the development of miniaturized, high-throughput robotic instrumentation, and the application of the two to advance biomolecular science. Their research program is in the emerging bio-nano field—at the intersection of bioMEMS, machine design, neuroengineering, genetics, optics, and manufacturing.

Roth Lab – UNC

Principal Investigator: Bryan Roth
UNC Neuroscience

Roth Lab studies the structure and function of G-Protein coupled receptors (GPCRs). Roth Lab is part of the Department of Pharmacology, a research department in the School of Medicine at the University of North Carolina at Chapel Hill. The Roth lab is the principal contractor for the NIMH Psychoactive Drug Screening Program which includes the PDSP Ki database.

Schnitzer Group – Stanford

Principal Investigator: Mark J Schnitzer
Stanford Neurosciencs Institute

The Schnitzer Group has three major research efforts: Development and application of fiber-optic, micro-optic, and nanophotonic imaging techniques for studies of learning and memory in behaving mice and for clinical uses in humans; In vivo fluorescence imaging and behavioral studies of hippocampal-dependent cognition and learning; and Development of high-throughput, massively parallel imaging techniques for studying brain function in large numbers of Drosophila concurrently

IDV – The Vision Institute

Research Director: Serge Picaud
Pierre and Marie Curie University

Built in the heart of the Quinze-Vingts National Eye Hospital, the Vision Institute is one of the most important research centers in Europe on eye diseases.The Institute's goal is to discover, test and develop treatments and technological innovations of tomorrow in order to prevent or limit visual impairment and to improve the autonomy and the quality of life of patients.

Laboratory of Neural Circuit Dynamics – Zurich

Principal Investigator: Fritjof Helmchen
Zurich Brain Research Institute

To study neural circuit function our research is focused on advancing and applying in vivo high-resolution imaging methods, with a particular emphasis on neocortical microcircuitry. The lab's specific goals are to reveal principles of single-cell and local network computation and to decipher the neural codes governing information processing as well as circuit plasticity.

Xu Research Group – Cornell

Principal Investigator, Chris Xu
Cornell University

Xu Research Group has two main thrusts: biomedical imaging and fiber optics. The Group is exploring new concepts and techniques for in vivo imaging deep into scattering biological specimens, such as mouse brain; developing new medical endoscopes for non-invasive real-time diagnostics of tissues without any exogenous contrast agent and novel optical fibers and fiber-based devices for biomedical imaging and optical communications.

Kanold Lab – UMD

Principal Investigator: Patrick Kanold
UMD Neuroscience and Cognitive Science

The major focus in the lab is to understand how information about the world is represented/encoded in the brain, the circuits present in the adult and developing brain and their influence of brain development and plasticity. One focus is on probing the response of the brain to sensory stimuli and the other is to record from small sub-circuits and study their responses and circuit behavior in great detail.

Grossman Institute – Chicago

Principal Investigator: John Maunsell
Neuroscience at University of Chicago

Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior is a new Institute designed to establish a group of scholars working at the intersection of quantitative biology, neuroscience, and the study of social and individual behaviors. The Institute will build upon existing strengths in these fields to address fundamental questions about the biological, social, and environmental factors that shape social behaviors and inter-individual variation in model organisms and humans.

David Kleinfeld Laboratory – UCSD

Principal Investigator: David Kleinfeld
UCSD Neuroscience; Neurophysics Research

Active sensation: how orofacial behaviors, with emphasis on the vibrissa sensorimotor system, encode a stable world view through actively moving sensors.
Microcirculation in the Brain: the structure and control of cortical blood flow, and variations in that flow, at the level of vascular networks down to that of individual microvessels.
CNiFERs: uses of cell-based sensors of signaling molecules to study volume transmission and neuromodulation in behaving animals.

Ecker Lab – Salk

Principal Investigator: Joseph R Ecker
Salk Institute for Biological Studies

Being able to study the epigenome in great detail and in its entirety will provide a better understanding of plant productivity and stress resistance, the dynamics of the human genome, stem cells’ capacity to self-renew and how epigenetic factors contribute to the development of tumors and disease. We are now exploring how DNA methylation effects the development of human embryonic stem (hES) cells as well as induced pluripotent stem (IPS) cells as they are induced to differentiate into other types of cells.

Nelson Lab – Brandeis

Principal Investigator: Sacha B. Nelson
Brandeis University

Despite their functional and clinical importance, the cell types that comprise the neocortex and the molecular mechanisms that specify their properties and connectivity are only partly understood. Nelson Lab studies the development and function of the neocortex in the laboratory mouse using a combination of genetic, genomic and electrophysiological approaches.

Sestan Lab – Yale

Principal Investigator: Nenad Sestan
Yale Neuroscience

The Sestan Lab's research centers on understanding the molecular and cellular basis of how neurons acquire distinct identities and form proper synaptic connections in the cerebral cortex, a part of the brain that is critical for cognition, perception and behavior. The Lab also studies how these complex developmental processes have evolved and become compromised in human disorders, such as autism. An important element of our research is the integration of complementary approaches.

Kit Lamb Lab – UCDavis

Principal Investigator: Kit S. Lam
UC Davis Center for Neuroscience

The main focus of the Lam Lab lies in discovering revolutionary and innovative methods of disease treatment on a nano-scale and molecular scale. The lab work is most related to molecular medicine, drug discovery, nanoparticle and drug-delivery techniques in cancer and other diseases. Our research is done through the use of cutting edge technologies and established procedures.

Optical Imaging Laboratory – Washington U

Principal Investigator: Lihong Wang
Washington University Neuroscience Program

Optical Imaging Laboratory develops novel biophotonic tomography for early-cancer detection and functional imaging, using non-ionizing electromagnetic and ultrasonic waves. Research directions include: Photo-acoustic tomography (PAT), Thermo-acoustic tomography (TAT), Ultrasound-modulated (acousto-) optical tomography (UOT), Mueller optical-coherence tomography (M-OCT), Oblique-incidence reflectometry (OIR) and spectroscopy, and Modeling light transport in tissues.

Yoon Lab – Michigan

Principal Investigator: Euisik Yoon
University of Michigan Neuroscience

SSEL has a very broad research program in all aspects of solid-state devices and technologies, including solid-state physics and theory, integrated photonics and optoelectronics, organic and molecular electronics, optical displays and devices, microwave devices and circuits, semiconductor materials, nanotechnology and nanofabrication, integrated RF, analog, digital, and VLSI circuits, solid-state sensors, actuators, micro electromechanical systems, and integrated microsystem.

Brefczynski-Lewis Lab – WVU

Principal Investigator: Julie Brefczynski-Lewis
WVU Center for Neuroscience

Brefczynski-Lewis Lab studies how we perceive people we love and people we don’t like, both famous and political, and how training in compassion can affect those perceptions. The Lab is examining the neural and physiological correlates of the liked and disliked persons and how these change after training in compassion. Grudge forgiveness study: fMRI response to the face of the grudge person, as well as cardio and reactive measures will be tested before and after the intervention.

Laboratory of Molecular Genetics – Rockefeller

Principal Investigator: Jeffrey M. Friedman
Senior Research Associate: Sarah Stanley
Rockefeller University

The application of modern methods in genetics has led to the identification of a new hormone, leptin, that regulates body weight. Leptin is an adipose tissue hormone that interacts with receptors in the brain to regulate food intake, energy expenditure and other neuroendocrine systems. The molecular mechanisms of leptin in the brain are under investigation. These studies are being conducted in parallel with efforts to identify obesity genes in the human.

Rubenstein Lab – UCSF

Principal Investigator: John L. R. Rubenstein
UCSF Neuroscience

The goal of Rubenstein Lab research is to elucidate fundamental mechanisms that regulate development of the forebrain, with a focus on the cerebral cortex and basal ganglia. Our studies also extend into other regions of the embryo, including the developing face. Whenever possible, we attempt to investigate whether disruption of these mechanisms underlie human disorders, such as autism, schizophrenia, mental retardation, epilepsy and craniofacial disorders.

X. William Yang Research Group – UCLA

Principal Investigator: X. William Yang
UCLA Neuroscience

Yang Lab's research is focused on applying comprehensive molecular and genetic approaches to study the pathogenesis of Huntington’s disease (HD) and Parkinson’s disease (PD), as well as exploring the molecular genetics and circuitry of the basal ganglia (BG), a brain region targeted in various neurodegenerative and neuropsychiatric disorders. The overarching approach of our lab is to develop genetic mouse models of these diseases, or create mice that carry mutations in the genes.

Scanziani Lab – UCSD

Principal Investigator: Massimo Scanziani
UC San Diego’s Neuroscience

The goal of Scanziani Lab's research is to understand the mechanisms by which elementary circuits of neurons control the spatial and temporal structure of cortical activity. Towards this goal they use in vivo and in vitro electrophysiological, imaging and anatomical techniques as well as behavioral approaches. Their model system is the rodent’s sensory cortex.

Laboratory of neural circuit formation – BU

Principal Investigator, Tim Gardner
Boston University (Charles River Campus)

The Gardner lab studies the mechanisms of temporal sequence perception and production, focusing on vocal learning in songbirds. The Laboratory of neural circuit formation current research projects involve: Sensory-motor learning; High-density recording and stimulating microelectrodes, Electrode arrays for the central nervous system: tissue interaction; and Peripheral nervous system : chronic recording and stimulation for biolectric medicine.

Mayo Physiology and Biomedical Engineering Dept.

Chair: Gary C. Sieck
Mayo Clinic

The Department of Physiology and Biomedical Engineering at Mayo has a long and rich history of scientists and physicians collaborating and translating basic discoveries. The department currently consists of 18 primary and 35 joint appointees. There are 34 doctoral students, 67 research fellows and research associates working in a variety of research areas.

Soltesz Lab – UCIrvine

Principal Investigator: Ivan Soltesz
UC Irvine Neuroscience

The Soltesz Lab is interested in how brain cells communicate with each other and how the communication changes after fever-induced seizures in early childhood and after head injury. Our general goal is to understand how neuronal networks function and dysfunction, in order to discover new therapies to prevent epilepsy.

Kramer Lab – Stanford

Principal Investigator: Richard Kramer
UC Berkeley Helen Wills Neuroscience Institute

Kramer Lab studies utilize novel chemical reagents to modify the function of ion channels and synapses. This Chemical-Biological approach is designed to allow non-invasive optical sensing and optical manipulation of channels and synapses in the nervous system. One major goal of this research is to develop the technology for restoring vision in degenerative blinding diseases.

Frank Laboratory – UCSF

Principal Investigator: Loren Frank
UCSF Neuroscience

The Frank Lab's goal is to understand how activity and plasticity in neural circuits underlie both learning and the ability to use learned information to make decisions. In particular, our laboratory focuses on the circuitry of the hippocampus and anatomically related regions. We use a combination of techniques, including large scale multielectrode recording, targeted optogenetic interventions and behavioral manipulations of awake, behaving animals to understand how the brain learns and remembers.

Center for Magnetic Resonance Research – Minnesota

Director: Kamil Ugurbil
Institute for Translational Neuroscience, University of Minnesota

Center for Magnetic Resonance Research (CMRR) focuses on development of unique magnetic resonance (MR) imaging and spectroscopy methodologies and instrumentation for the acquisition of structural, functional, and biochemical information non-invasively in humans, and utilizing this capability to investigate organ function in health and disease. The distinctive feature of CMMR is the emphasis on ultrahigh magnetic fields (7 Tesla and above).

Center of Regeneration Medicine and Stem Cell Research – UCSF

Director: Arnold Kriegstein
UCSF Neuroscience

The Center's organization is designed to foster collaborations derived from work on different organs and tissue systems. Accordingly, the laboratories and research efforts are organized along a series of pipelines, each focusing on a particular tissue or organ system, and including basic research as well as translational research directed toward clinical applications. A basic researcher and a clinician direct each pipeline

Geschwind Lab – UCLA

Principal Investigator: Daniel H Geschwind
UCLA Neuroscience

The Geschwind laboratory is dedicated to improve treatment and understanding of neurodevelopmental and neurodegenerative conditions, focusing on autism spectrum disorders, dementia, neural repair, and inherited ataxia. The lab leverages the fields of genetics and genomics, coupled with basic neurobiology, to obtain a systems level understanding of disease. The lab has pioneered the application of gene expression and network methods in neurologic and psychiatric disease.

Tsien Lab – UCSD

Principal Investigator: Roger Tsien
Research Scientist: John Yu-Luen Lin

The multicolored fluorescent proteins developed in Tsien's lab are used by scientists to track where and when certain genes are expressed in cells or in whole organisms. Typically, the gene coding for a protein of interest is fused with the gene for a fluorescent protein, which causes the protein of interest to glow inside the cell when the cell is irradiated with ultraviolet light and allows microscopists to track its location in real time. This is such a popular technique that it has added a new dimension to the fields of molecular biology, cell biology, and biochemistry.

Rinsberg Lab – NYU

Principal Investigator: Dimitri Rinsberg
NYU Neuroscience Institute

Rinsberg's lab has been focused on temporal aspects of olfactory coding. They recently discovered that a) olfactory neuronal code at the level of olfactory bulb is temporally very precise (~10 ms) [Shusterman-2011], and b) the mammalian olfactory system can read and interpret temporal patterns at this time scales [Smear-2011]. The lab's efforts are directed towards establishing causal connection between neuronal coding and animal behavior.

Tian Lab – UC Davis

Principal Investigator: Lin Tian
UC Davis Neuroscience

The goal of Tian Lab's research is to invent new molecular tools for analyzing and engineering functional neural circuits. We also leverage these tools, combined with optical imaging techniques, to study molecular mechanisms of neurological disorders at system level and to empower searching for novel therapeutic treatments.

Pediatric Epilepsy Research Lab- Mass General

Principal Investigator: Kevin J. Staley
Neuroscience@Harvard, Massachusetts General Hospital

The lab's research goal is the development of new approaches to the treatment of epilepsy based on a clearer understanding of the necessary steps in seizure initiation and propagation. The two major themes in the lab are neuronal ion transport and the spread of activity in neural networks combining fluorescent imaging of network activity with computerized analysis and modeling to understand how normal and abnormal signaling progresses through neural networks.

Sanes Lab – Harvard

Principal Investigator: Joshua R Sanes

The Sanes Lab wants to learn how neural circuits are assembled in young animals and how they process information in adults. A particular focus is identification and analysis of synaptic recognition molecules responsible for the amazing specificity of connections that underlies complex neural processing. We use a combination of genetic, molecular, histological and electrophysiological approaches to address these issues. Our main model system is the mouse retina.

John B. Pierce Laboratory – Yale

Fellow: Vincent Allen Pieribone
Yale Interdepartmental Neuroscience Program

The John B. Pierce Laboratory is a nonprofit, independent research institute that is formally affiliated with Yale University. The Laboratory has a long and distinguished history as a leading center for the study of physiological regulatory systems such as those that maintain body temperature, respiration, body fluids, and metabolism within healthy limits.

Section of High Resolution Brain PET Imaging

Director: Dean Foster Wong
John Hopkins School of Medicine

John Hopkins neuroimaging specialists will develop a noninvasive way of measuring human brain neuronal activity and chemical changes in milliseconds as opposed to several minutes, as in current PET scans. The new technique will also be much more sensitive to neurochemical processes than other imaging techniques, including functional magnetic resonance imaging and magnetoencephalographic recording of brain magnetic fields

Osten Lab – CSHL

Principal Investigator: Pavel Osten
Cold Spring Harbor Laboratory

Osten’s lab works on identification and analysis of brain regions, neural circuits, and connectivity pathways that are disrupted in genetic mouse models of autism and schizophrenia. Osten and colleagues have developed the first systematic approach to the study of neural circuits in mouse models of psychiatric diseases, based on a pipeline of anatomical and functional methods for analysis of mouse brain circuits employing serial two-photon (STP) tomography.

Engert Lab – Harvard

Director: Florian Engert
Program in Neuroscience @Harvard

The general goal of the laboratory is the comprehensive identification and examination of neural circuits controlling behavior using the larval zebrafish as a model system. To that end, we have established and quantified a series of visually induced behaviors and analyzed the individual resulting motor components. An extended goal is the study of how changes or variations in the behavior are reflected in changes in the underlying neuronal activity.

Biophotonics Laboratory – Caltech

Principal Investigator: Changhuei Yang
Caltech Neuroscience

The Biophotonics Laboratory is focused on the development of novel tools that combine optics and microfluidics to tackle diagnostic and measurement problems in biology and medicine. The major techniques that are under development in the laboratory include the ePetri, Fourier Ptychographic microscopy, and time-reversal optical focusing.

Roukes Group – CalTech

Director: Michael Roukes
Caltech Neuroscience

The Roukes Group is working to explore new physics at the nanoscale, and to apply this knowledge to realizing advanced tools for the biomedical and life sciences. Our group's current focus is on (a) next-gen methods for neuroscience enabled by very-large-scale integration of nanoelectronic and nanophotonic devices, (b) single-molecule mass spectrometry and molecular analysis enabled by arrays of nanoelectromechanical systems (NEMS), and (c) on the fundamental physics of NEMS.

Duke-UNC Brain Imaging & Analysis Center

Director: Allen W Song
Duke Institute for Brain Sciences

The Brain Imaging and Analysis Center (BIAC) brings together scientists from throughout Duke University and the University of North Carolina at Chapel Hill to find interdisciplinary solutions to fundamental research questions about the human brain. Two key themes: to improve research techniques in neuroimaging and investigate the functional properties of the human brain.

Hobert Lab – Columbia

Principal Investigator: Oliver Hobert
Columbia Neuroscience

The main focus of the laboratory is to understand the molecular mechanisms that generate the astounding diversity of cell types in a nervous system. Using the C.elegans model system, they have revealed a core regulatory logic for how terminal neuronal identity is controlled in several different neuron types and have demonstrated that these regulatory mechanisms are conserved in chordates.

Dickinson Lab – Caltech

Principal Investigator, Michael Dickinson
Caltech Neuroscience

The Dickinson Lab studies the neural and biomechanical basis of behavior in the fruit fly, Drosophila. We strive to build an integrated model of behavior that incorporates an understanding of morphology, neurobiology, muscle physiology, physics, and ecology. Although our research focuses primarily on flight control, we are interested in how animals transform sensory information into a code that controls motor output and behavior.

Tsao Lab – Caltech

Principal Investigator: Doris Ying Tsao
California Institute of Technology

Tsao Lab explores the neural mechanisms underlying primate vision: how visual objects are represented in the brain, and how these representations are used to guide behavior. How does the brain stitch together pixels into invariant, discrete recognizable objects in space? This is the problem our lab is trying to solve. We are tackling it through study of the monkey brain, the mouse brain, and mathematical modeling. In addition, we are developing a new technique to study the human brain.

Hannon Lab – CSHL

Principal Investigator, Greg Hannon
Cold Springs Harbor Laboratory

The Hannon Lab comprises a broad spectrum of programs in small RNA biology, mammalian genetics and genomics. The Hannon Lab studies RNAi and related pathways in a wide variety of organisms to extract common themes that define both the mechanisms by which small RNAs act and the biological processes which they impact. Current focus is on microRNAs, endogenous siRNAs and piRNAs and their roles in gene regulation, cancer biology, stem cell biology and in defense of the genome against transposons

Ngai Lab

Helen Wills Neuroscience Institute
Director, John Ngai

The Ngai Lab focuses on the molecular mechanisms underlying the development and function of the vertebrate olfactory system using molecular, genomic, computational and behavioral approaches. The Ngai Lab is also leveraging high-throughput genomic and genome engineering techniques. Ngai Lab aims to make significant discoveries on the molecules, cells and circuits underlying the development, regeneration and function of the nervous system during normal processes and disease.

Nedivi Lab – MIT

Principal Investigato, Elly Nedivi
MIT Neuroscience

Plasticity is a prominent feature of brain development, and in the adult underlies learning and memory and adaptive reorganization of sensory maps. The Nedivi lab, part of the Picower Institute for Learning and Memory, studies the cellular mechanisms that underlie activity-dependent plasticity in the developing and adult brain through studies of neuronal structural dynamics, identification of the participating genes, and characterization of the proteins they encode.

Jasanoff Lab – MIT

Principal Investigator, Alan Jasanoff
MIT Neuroscience

Jasanoff Lab is developing a new generation of functional magnetic resonance imaging (fMRI) methods to study the neural mechanisms of behavior.The Lab's focus is on the design and application of new contrast agents that may help define spatiotemporal patterns of neural activity with far better precision and resolution than current techniques allow. Experiments using the new agents will combine the specificity of cellular neuroimaging with the whole brain coverage and noninvasiveness of conventional fMRI.

Desimone Laboratory – MIT

Principal Investigator, Robert Dismone
MIT Neuroscience

Desimone is interested in how the brain deals with the challenge of information overload. Some messages contain relevant information, but many do not. By studying the visual system of humans and animals, Desimone has shown that relevant information is selectively amplified in certain brain regions, while irrelevant information is suppressed. One reason this happens is that neurons whose activity reflects the relevant information become synchronized with one another.

Synthetic Neurobiology Group – MIT

MIT Neuroscience
Principal Investigator: Ed Boyden, Ph.D.

The Synthetic Neurobiology Group develops tools that enable the mapping of the molecules and wiring of the brain, the recording and control of its neural dynamics, and the repair of its dysfunction.The Group applies these to the systematic analysis of brain computations, aiming to reveal the fundamental mechanisms of brain function, and yielding new, ground-truth therapeutic strategies for neurological and psychiatric disorders.

Laboratory of Mriganka Sur – MIT

Principal Investigator: Mriganka Sur
MIT Neuroscience

The goal of the Sur Lab is to understand long-term plasticity and short-term dynamics in networks of the developing and adult cortex, and how disruption of any of these network properties leads to brain disorders. Development of real time, high-speed imaging, activity-sensitive dyes, and light-sensitive ion channels are currently fueling the Lab's exploration of the varied and plastic networks these cells form.

Seung Lab – Princeton

Principal Investigator: Sebastian Seung
Princeton Neuroscience Institute

The Seung Lab uses techniques from machine learning and social computing to extract brain structure from light and electron microscopic images. EyeWire showcases our approach by mobilizing gamers from around the world to create 3D reconstructions of neurons by interacting with a deep convolutional network. The Seung Lab also develops computational methods for relating brain structure to function. Seung Lab is best known for our work on the reconstruction of neural circuits using serial electron microscopy.

Genetic Neuroengineering Group

Head: Ian Wickersham
MIT Neuroscience

Research interests: viral vector engineering, synthetic biology. Engineering genetic tools for neuroscience.

Brodylab – Princeton

Principal Investigator: Carlos D Brody
Princeton Neuroscience Institute

Brodylab's focus is on novel quantitative behaviors that allow exploring high-level cognitive questions using powerful emerging tools for studying neural mechanisms in rats. The lab now uses rats to investigate the neural bases of decision making, working memory and executive control using a combination of high-throughput semiautomated behavior as well as computational, electrophysiological, pharmacological and optogenetic methods.

Advanced MRI Technologies (AMRIT)

President, Advanced MRI Technologies (AMRIT)

AMRIT is a research and development company in the field of medical and scientific imaging. The main objective is to find new uses for MRI and to provide the technical knowledge needed to conduct medical and neuroscience studies with the advanced MRI methods. The specific focus of AMRIT is in brain, heart and cancer studies with magnetic resonance imaging.

Center for Biomedical Imaging

Principal Investigator: Lawrence Wald

The Martinos Center for Biomedical Imaging dual mission includes translational research using state-of-the-art imaging technologies and ongoing development of those technologies. The core technologies being developed and used at the Center include magnetic resonance imaging (MRI), positron emission tomography (PET) and more (see the navigation menu on the left for a complete list of the technologies). A key area of innovation is Multimodal Functional Neuroimaging.

Flinn Lab – GMU

Director, Jane Flinn

The Flinn Lab is interested in the biological bases of learning and memory. Current research focuses on the role of metals in normal memory and in Alzheimer's disease (AD).

Zinc, iron and copper are all elevated in the plaques found in the brains of people with AD.

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