Cold Spring Harbor Laboratory

Cold Spring Harbor Laboratory (CSHL) is a private, not-for-profit research and education institution at the forefront of molecular biology and genetics.

CSHL research generates knowledge that will yield better diagnostics and treatments for cancer, neurological diseases and other major diseases, and that will lead to improved and more diverse food resources and more efficient biofuels. The Watson School of Biological Sciences trains the next generation of scientists through an innovative Ph.D. program and other educational offerings.

Optogenetic toolkit for control of cells

PI: Gregory Hannon, Hannon Lab
Institution: Cold Spring Harbor Laboratory
Title: "An optogenetic toolkit for the interrogation and control of single cells."
BRAIN Category: Tools for Cells and Circuits (RFA MH-14-216)

Dr. Hannon's group will develop optogenetic techniques that use pulses of light to control genes and isolate proteins in specific cell types in the brain for molecular studies.

Mapping the mouse brain in 3-D

The mapping of the mouse brain is giving researchers like Partha Mitra a better understanding of how neurons are connected and how they communicate across the regions of the brain.

Pavel Osten, MD, PhD – CSHL

Associate Professor, Cold Spring Harbor Laboratory
Principal Investigator: Osten Lab

To understand what’s going wrong in illnesses like autism and schizophrenia, we need to know more about how neural circuits are connected in the healthy brain. We’ve developed advanced imaging methods to draw the first whole-brain activation map in the mouse. Now we’re applying that technology to study changes in brain activity in mice whose behavior models human autism and schizophrenia.

Hannon Lab – CSHL

Principal Investigator, Greg Hannon
Cold Springs Harbor Laboratory

The Hannon Lab comprises a broad spectrum of programs in small RNA biology, mammalian genetics and genomics. The Hannon Lab studies RNAi and related pathways in a wide variety of organisms to extract common themes that define both the mechanisms by which small RNAs act and the biological processes which they impact. Current focus is on microRNAs, endogenous siRNAs and piRNAs and their roles in gene regulation, cancer biology, stem cell biology and in defense of the genome against transposons.

Gregory Hannon, PhD – CSHL

Professor at Cold Springs Harbor Laboratory & HHMI Investigator
Principal Investigator, Hannon Lab

Greg Hannon explores the processes that cells use to turn genes on and off. My work is focused on understanding a relatively new class of cellular pathways, governed by molecules known as small RNAs, that control gene activation and repression. Our studies of small-RNA biology in early development provide insights into human evolution, diversity, and diseases such as cancer.

Quantitative cell type-based mapping

Principal Investigator: Pavel Osten
Cold Spring Harbor Laboratory
Title: "Towards quantitative cell type-based mapping of the whole mouse brain"
BRAIN Category: Census of Cell Types (RFA MH-14-215)

The Osten team will develop an automated system to image different types of brain cells and their connections in mice, to pinpoint differences between males and females, across the lifespan.

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