Institute for Neuroscience @Yale

The Kavli Institute for Neuroscience at Yale University studies the neurobiological basis of human thought. Following a broad multidisciplinary strategy, it examines how the nerve cells and synaptic circuits of the cerebral cortex enable humans to learn about the outside world and to remember what they already have learned.

Toward this end, it fosters discussion and innovative research among Yale neuroscientists from multiple disciplines, enabling them to contribute novel ideas and approaches in research on cortical evolution, development, organization and function.

Yale Neuroscience

Yale University's neuroscience research and academic programs are located in the Faculty of Arts and Science and the School of Medicine.

The interdisciplinary research programs of Yale neuroscience faculty are central to Yale's Interdepartmental Neuroscience Program (INP). Other major groups are the Kavli Institute for Neuroscience which awards grants to Yale faculty to support new research initiatives and the Center for Neuroscience and Regenerative Research which is dedicated to molecular and cell-based discoveries.

Big Think Interview With Vincent Pieribone

A conversation with the associate professor at Yale University.

Video published on April 23, 2012 by Big Think

Sestan Lab – Yale

Principal Investigator: Nenad Sestan
Yale Neuroscience

The Sestan Lab's research centers on understanding the molecular and cellular basis of how neurons acquire distinct identities and form proper synaptic connections in the cerebral cortex, a part of the brain that is critical for cognition, perception and behavior. The Lab also studies how these complex developmental processes have evolved and become compromised in human disorders, such as autism. An important element of our research is the integration of complementary approaches.

Nenad Sestan, MD/PhD – Yale

Professor of Neurobiology, of Genetics and of Psychiatry, Yale University
Director, Sestan Lab

Research Interests- the evolution and development of neuronal circuits of the human cerebral cortex. Research in the Sestan Lab investigates how neurons acquire distinct identities and form precise connections in the developing cerebral cortex, a part of the brain involved in a variety of higher cognitive, emotional, sensory, and motor functions. The Lab also studies how these developmental processes have changed during evolution and in human disorders.

John B. Pierce Laboratory – Yale

Fellow: Vincent Allen Pieribone
Yale Interdepartmental Neuroscience Program

The John B. Pierce Laboratory is a nonprofit, independent research institute that is formally affiliated with Yale University. The Laboratory has a long and distinguished history as a leading center for the study of physiological regulatory systems such as those that maintain body temperature, respiration, body fluids, and metabolism within healthy limits.

Vincent Allen Pieribone, PhD – Yale

Professor of Cellular and Molecular Physiology and of Neurobiology, Yale University
Fellow, John B. Pierce Laboratory

Dr Pieribone is developing genetically encoded fluorescent probes of membrane electrical potential. These probes allow one to use optical instruments (microscopes) to monitor the electrical activity of neurons. He has also engineered miniature imaging systems that can be head mounted on mammels and allow mobile recording of neuronal activity.

Protein-based Voltage Probes

Principal Investigator: Vincent Allen Pieribone
Yale Interdepartmental Neuroscience Program
Title: "Development of Protein-based Voltage Probes"
BRAIN Category: Large-Scale Recording-Modulation - Optimization (RFA NS-14-008)

Dr. Pieribone and his team will optimize fluorescent voltage probe technology, to allow scientists to measure the activity of thousands of neurons using only a camera and a microscope.

Cell-Type Classification in the Human Brain

Principal Investigator: Nenad Sestan
Yale Neuroscience
Title: "A Novel Approach for Cell-Type Classification and Connectivity in the Human Brain"
BRAIN Category: Census of Cell Types (RFA MH-14-215)

Dr. Sestan's group will substantially advance the profiling of cell types – their molecular identities and connections – made possible by a new method of better preserving brain tissue to maintain cell integrity.

Skip to toolbar