UNC Neuroscience

The UNC Neuroscience Center is an interdepartmental research center at the UNC-Chapel Hill School of Medicine.

The mission of the Neuroscience Center is to promote neuroscience research that is innovative, collaborative and translational. The Center promotes this goal by bringing together researchers working on fundamental problems in basic and clinical neuroscience. By integrating work across the spectrum of neuroscience, we aim to advance our understanding of brain development and function, and to identify new therapeutic approaches to a broad range of neurological and psychiatric disorders.

Dreadd2.0: A Chemogenetic Toolkit

Principal Investigator: Bryan L Roth
UNC Neuroscience
Title: " Dreadd2.0: An Enhanced Chemogenetic Toolkit"
BRAIN Category: Tools for Cells and Circuits (RFA MH-14-216)

Dr. Roth and colleagues will build second generation technology that uses artificial neurotransmitters and receptors to manipulate brain activity simultaneously across select cells and pathways to understand their functions and potentially treat brain disorders.

Bryan Roth, MD/PhD – UNC

Professor. Department of Pharmacology, University of North Carolina
Director, NIMH Psychoactive Drug Screening Program
Director, Roth Lab

Roth studies all aspects of GPCR structure and function ranging from the atomic-level analysis of ligand-receptor interactions to in vivo studies. Currently he is focused on members of the serotonin (5-hydroxytryptamine; 5-HT) and opioid receptor families and their accessory proteins.

Roth Lab – UNC

Principal Investigator: Bryan Roth
UNC Neuroscience

Roth Lab studies the structure and function of G-Protein coupled receptors (GPCRs). Roth Lab is part of the Department of Pharmacology, a research department in the School of Medicine at the University of North Carolina at Chapel Hill. The Roth lab is the principal contractor for the NIMH Psychoactive Drug Screening Program which includes the PDSP Ki database.

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