Precision Biosystems Laboratory – Ga. Tech

Principal Investigator: Craig Forest

The Precision Biosystems Laboratory is focused on fundamental engineering advancements, the development of miniaturized, high-throughput robotic instrumentation, and the application of the two to advance biomolecular science. Their research program is in the emerging bio-nano field—at the intersection of bioMEMS, machine design, neuroengineering, genetics, optics, and manufacturing.

Roth Lab – UNC

Principal Investigator: Bryan Roth
UNC Neuroscience

Roth Lab studies the structure and function of G-Protein coupled receptors (GPCRs). Roth Lab is part of the Department of Pharmacology, a research department in the School of Medicine at the University of North Carolina at Chapel Hill. The Roth lab is the principal contractor for the NIMH Psychoactive Drug Screening Program which includes the PDSP Ki database.

Laboratory of Molecular Genetics – Rockefeller

Principal Investigator: Jeffrey M. Friedman
Senior Research Associate: Sarah Stanley
Rockefeller University

The application of modern methods in genetics has led to the identification of a new hormone, leptin, that regulates body weight. Leptin is an adipose tissue hormone that interacts with receptors in the brain to regulate food intake, energy expenditure and other neuroendocrine systems. The molecular mechanisms of leptin in the brain are under investigation. These studies are being conducted in parallel with efforts to identify obesity genes in the human.

Rubenstein Lab – UCSF

Principal Investigator: John L. R. Rubenstein
UCSF Neuroscience

The goal of Rubenstein Lab research is to elucidate fundamental mechanisms that regulate development of the forebrain, with a focus on the cerebral cortex and basal ganglia. Our studies also extend into other regions of the embryo, including the developing face. Whenever possible, we attempt to investigate whether disruption of these mechanisms underlie human disorders, such as autism, schizophrenia, mental retardation, epilepsy and craniofacial disorders.

X. William Yang Research Group – UCLA

Principal Investigator: X. William Yang
UCLA Neuroscience

Yang Lab's research is focused on applying comprehensive molecular and genetic approaches to study the pathogenesis of Huntington’s disease (HD) and Parkinson’s disease (PD), as well as exploring the molecular genetics and circuitry of the basal ganglia (BG), a brain region targeted in various neurodegenerative and neuropsychiatric disorders. The overarching approach of our lab is to develop genetic mouse models of these diseases, or create mice that carry mutations in the genes.

Pediatric Epilepsy Research Lab- Mass General

Principal Investigator: Kevin J. Staley
Neuroscience@Harvard, Massachusetts General Hospital

The lab's research goal is the development of new approaches to the treatment of epilepsy based on a clearer understanding of the necessary steps in seizure initiation and propagation. The two major themes in the lab are neuronal ion transport and the spread of activity in neural networks combining fluorescent imaging of network activity with computerized analysis and modeling to understand how normal and abnormal signaling progresses through neural networks.

Hobert Lab – Columbia

Principal Investigator: Oliver Hobert
Columbia Neuroscience

The main focus of the laboratory is to understand the molecular mechanisms that generate the astounding diversity of cell types in a nervous system. Using the C.elegans model system, they have revealed a core regulatory logic for how terminal neuronal identity is controlled in several different neuron types and have demonstrated that these regulatory mechanisms are conserved in chordates.

Hannon Lab – CSHL

Principal Investigator, Greg Hannon
Cold Springs Harbor Laboratory

The Hannon Lab comprises a broad spectrum of programs in small RNA biology, mammalian genetics and genomics. The Hannon Lab studies RNAi and related pathways in a wide variety of organisms to extract common themes that define both the mechanisms by which small RNAs act and the biological processes which they impact. Current focus is on microRNAs, endogenous siRNAs and piRNAs and their roles in gene regulation, cancer biology, stem cell biology and in defense of the genome against transposons.

Synthetic Neurobiology Group – MIT

MIT Neuroscience
Principal Investigator: Ed Boyden, Ph.D.

The Synthetic Neurobiology Group develops tools that enable the mapping of the molecules and wiring of the brain, the recording and control of its neural dynamics, and the repair of its dysfunction.The Group applies these to the systematic analysis of brain computations, aiming to reveal the fundamental mechanisms of brain function, and yielding new, ground-truth therapeutic strategies for neurological and psychiatric disorders.

Genetic Neuroengineering Group

Head: Ian Wickersham
MIT Neuroscience

Research interests: viral vector engineering, synthetic biology. Engineering genetic tools for neuroscience.

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