Open Worm

OpenWorm is an international open science project to simulate the roundworm Caenorhabditis elegans at the cellular level as a simulation.

Although the long-term goal is to model all 959 cells of the C. elegans, the first stage is to model the worm's locomotion by simulating the 302 neurons and 95 muscle cells. This bottom up simulation is being pursued by the OpenWorm community.

Eyewire, game to map the brain

EyeWire is a game to map the brain in collaboration with Seung Lab at Princeton. Anyone can play and you need no scientific background — over 200,000 people from 145 countries already do.

Together we are mapping the 3D structure of neurons; advancing our quest to understand ourselves.

BHM Project

The BHM - Biorealistic Hippocampal Modeling - project's goal is to conceptualize a cognitive processor inspired by evolutionarily prescribed biological systems.

The hippocampal formation computational component of this processor is based on biologically realistic circuitry derived from This highly curated open-access resource defines rodent hippocampal neuron types primarily based on axonal-dendritic patterning and is informed through dense coverage of peer-reviewed literature.

Neurodata without Borders

The Neurodata Without Borders: Neurophysiology (“NWB”) format is designed to store a variety of neurophysiology data, including from intracellular and extracellular electrophysiology experiments, optical physiology experiments, as well as tracking and stimulus data.

The NWB format is implemented in the Hierarchical Data Format (HDF5) and is designed to store data in a self-documenting way. The storage schema is described by a specification language and it is extensible to support future scientific needs as well as lab-specific requirements.

Human Connectome Project

The Human Connectome Project (HCP) is a five-year project sponsored by the National Institutes of Health, split between two consortia of research institutions. The project was launched in July 2009 as the first of three Grand Challenges of the NIH's Blueprint for Neuroscience Research.

The goal of the Human Connectome Project is to build a "network map" that will shed light on the anatomical and functional connectivity within the healthy human brain, as well as to produce a body of data that will facilitate research into brain disorders. – Wikipedia for Neurons

To help scientists make sense of this “brain big data,” researchers at Carnegie Mellon University have used data mining to create, a publicly available website that acts like Wikipedia, indexing physiological information about neurons.

The site will help to accelerate the advance of neuroscience research by providing a centralized resource for collecting and comparing data on neuronal function.

Engineer the Tools of Scientific Discovery

One of the National Academy of Engineering’s 14 Grand Challenges is how to “Engineer the Tools of Scientific Discovery.”

Grand experiments and missions of exploration always need engineering expertise to design the tools, instruments, and systems that make it possible to acquire new knowledge about the physical and biological worlds web based repository A web-based repository for collecting and sharing unthresholded statistical maps of the human brain,

NeuroVault allows researchers to store, share, visualize, and decode statistical maps of the human brain. NeuroVault is easy to use and leverages the power of the Neurosynth database to provide cognitive decoding of deposited maps.

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