MCWG Meeting July 30, 2015

NIH BRAIN Initiative Multi-Council Working Group Meeting (MCWG) met on July, 30 2015. Videocast coming soon.

10:15 am - Update on BRAIN
10:30 am - Opportunities for Collaboration
11:40 am - Group Discussion
12:45 pm - Neuroethics
1:15 pm - FY 16 Plans
3:00 pm - FY 17 and Beyond

For more information on previous MCWG meetings and members, go to "Working Group"under the "About" menu.


August 25, 2014 MCWG meeting

The purpose of the working group is to provide input on a variety of issues to the advisory councils of the 10 NIH Institutes participating in the BRAIN Initiative.

The meeting included an overview of the BRAIN Initiative, an overview of the working group’s responsibilities, and a discussion of the applications received in response to the NIH’s initial six BRAIN Initiative funding announcements. In the afternoon, concepts for potential future BRAIN funding announcements were presented for input and approval

President Obama on the BRAIN Initiative

President Barack Obama launches the BRAIN Initiative on April 2, 2013. The video in this post was titled "President Obama Speaks on the BRAIN Initiative and American Innovation."

..."President Obama unveils a bold new research initiative designed to revolutionize our understanding of the human brain, and discusses the importance of investing in American innovation to create jobs and strengthen our economy."

Published on YouTube by the White House April 2, 2013.

NIH Neuroscience Challenges

NIH Data Science Distinguished Seminar Series
Towards Solutions to Experimental and Computational Challenges in Neuroscience
Air date: Friday, August 14, 2015, 11:00 AM videocast

Drs. Christof Koch and Emery Brown will describe the computational or experimental challenges associated with Big Data in their respective domains of neuroscience. From the basic to applied realms, science is being transformed by the collection of data on increasingly finer resolutions, both spatially and temporally. Storing, accessing, and analyzing these data create numerous challenges and opportunities.

From Neurons to Neighborhoods: Tom Insel

"From Neurons to Neighborhoods: charting a new science of mental health"

Dr. Thomas Insel, Director of the National Institute of Mental Health (NIMH), discusses how a deeper understanding of how the human brain functions will yield new approaches to diagnostics and therapeutics, bending the curve for millions affected by mental disorders.

Published by Stanford on October 20, 2014

Early Days of the NIH BRAIN initiative

Walter Koroshetz presentation at Neuroscience BioConference Live [online] conference on Mar 19, 2015.

From Labroots synopsis: "The major funded efforts at this time fit into 3 main categories; 1) defining the components of brain circuits, i.e., a cell census; 2) developing and testing tools for recording high density information on circuit structure, activity, and manipulating circuit activity; 3) novel technology for noninvasive interrogation and manipulation of circuit activity (next generation imaging)."

The Brain’s Inner Workings: Cognition

How People Think: "The Brain's Inner Workings: Cognition"

"...from the National Institute of Mental Health (NIMH) - this video narrated by Tom Bosley looks at the neurological basis of higher brain function. Learn how different human behaviors and functions can be isolated to specific areas of the brain, and how with the help of imaging techniques like MRI we can visualize brain activity in a way that gives insight into how the brain functions and allows scientists to develop..."

NIMH Hangout on First-Episode Psychosis

The National Institute of Mental Health (NIMH) hosted a Hangout during National Children’s Mental Health Awareness Week on first-episode psychosis with NIMH expert Amy Goldstein, Ph.D. and NIMH grantee and psychiatrist John Kane, M.D.

Each year, about 100,000 young people in the U.S. experience a first episode of psychosis.

Streamed live on May 5, 2015

Science in 3D: 2015 Bioinformatics Festival

Day one videocast: Morning sessions included 3D printed Eyewire neurons by James Drake and Oculus fly through the brain.

Afternoon seesions included strategies for how to implement open source bio printing accessible and inexpensive... available for research. NIH 3D printer exchange is creating file formats for bioprinting cell types.

Fattah Neuroscience Initiative

The Fattah Neuroscience Initiative (FNI) is a policy initiative designed to make major progress in understanding the human brain by intensifying federal research efforts across brain disease, disorder, injury, cognition and development.

The initiative aims to coordinate research across agencies and draw upon public-private partnerships and the world of academia. Congressman Fattah is the lead Democrat on the Commerce, Justice, Science Appropriations Subcommittee overseeing federal expenditures in the science agencies.

Toward a new understanding of mental illness

Today, thanks to better early detection, there are 63% fewer deaths from heart disease than there were just a few decades ago. Thomas Insel, Director of the National Institute of Mental Health, wonders: Could we do the same for depression and schizophrenia? The first step in this new avenue of research, he says, is a crucial reframing: for us to stop thinking about "mental disorders" and start understanding them as "brain disorders."

Filmed January 203 at TEDX Caltech
Uploaded to YouTube on April 16, 2013 by TED

National Advisory Neurological Disorders and Stroke (NANDS) Council Meetings

September 10, 2015 Meeting

Natcher Conference Center, Building 45, Conference Room E1/E2
Bethesda, Maryland 20892
Closed Circuit Viewing Overflow on September 10 (Conference Rooms F1/F2 and D)
NIH Videocast Website:

NIH Neuroscience Seminar- June 15, 2015

TITLE: Photo-control of endogenous ion channels and neurotransmitter receptors in the CNS

AUTHOR: Richard Kramer, Ph.D., University of California, Berkeley

TIME: 12:00:00 PM DATE: Monday, June 15, 2015

PLACE: Porter Neuroscience Research Center

Live NIH Videocast (archived after seminar)

NIH Neuroscience Seminar- June 8, 2015

TITLE: What goes out must come in: coupling of synaptic exo- and endocytosis

AUTHOR: Jurgen Klingauf, Ph.D.

TIME: 12:00:00 PM DATE: Monday,June 8, 2015

PLACE: Porter Neuroscience Research Center

Live NIH Videocast (archived after seminar)

NIH Neuroscience Seminar- June 1, 2015

TITLE: Rethinking Depression and its Treatment: Perspectives from Studies of Deep Brain Stimulation

AUTHOR: Helen Mayberg, M.D., Emory University

TIME: 12:00:00 PM DATE: Monday, June 1, 2015

PLACE: Porter Neuroscience Research Center

Live NIH Videocast (archived after seminar)

NIH Neuroscience Seminar- May 18, 2015

TITLE: Neural mechanisms of real-time decisions

AUTHOR: Paul Cisek, Ph.D., University of Montreal

TIME: 12:00:00 PM DATE: Monday, May 18, 2015

PLACE: Porter Neuroscience Research Center

Live NIH Videocast (archived after seminar

NIH Neuroscience Seminar- May 11, 2015

TITLE: Genetic risk for Alzheimer's disease: an emerging role for rare variants

AUTHOR: Alison Goate, PhD, Mount Sinai School of Medicine

TIME: 12:00:00 PM DATE: Monday, May 11 2015

PLACE: Porter Neuroscience Research Center

NIH Videocast

NIH Neuroscience Seminar- May 4, 2015

TITLE: Family Genomics of Bipolar Disorder

AUTHOR: Jared Roach, M.D., Ph.D., Institute for Systems Biology

TIME: 12:00:00 PM  DATE: Monday, May 4, 2015

PLACE: Porter Neuroscience Research Center

 NIH Videocast 




Senior Research Scientist Family Genomics Group Institute for Systems Biology

Dr. Roach is interested in basic and translational analyses and applications of high-throughput systems-biology data. He is currently focusing on understanding the genetics of complex neurodegenerative diseases, including Huntington’s Disease. Areas of expertise: Computational Biology, Genetics, Genomics, and Immunology

Web Information

Personal webpage: ISB Webpage: Family Genomics Group webpage:

Contact Information

Email: Phone: 206) 732-2108 Address: 2616 24th Ave East Seattle, WA 98112

Related Research

Dr. Roach’s research interests include analysis of MHC haplotypes and their relationship to risk and etiology of type 1 diabetes and other autoimmune diseases. Dr. Roach is pioneering approaches for the analysis of whole genome sequencing data in the context of family pedigrees. His past studies have included (1) the systems biology of the macrophage, particularly in its role as an information processing device, at the levels of cell surface receptors, signal transduction, and nuclear regulation, (2) the molecular phylogenetics of vertebrate gene families, particularly those genes relevant to macrophage information processing, and (3) analysis and interpretation of transcript enumeration data, ...

NIH Neuroscience Seminar- April 27, 2015

TITLE: NMDA receptor trafficking and synaptic dysfunction in Huntington disease

AUTHOR: Lynn A. Raymond, MD, PhD, University of British Columbia

TIME: 12:00:00 PM DATE: Monday, April 27, 2015

PLACE: Porter Neuroscience Research Center

Live NIH Videocast (archived after seminar)

NIH Neuroscience Seminar- April 13, 2015

TITLE: Mechanisms of ubiquitin signaling in gene regulation and chromatin dynamics

AUTHOR: Cynthia Wolberger, Ph.D., Johns Hopkins University

TIME: 12:00:00 PM DATE: Monday, April 13, 2015

PLACE: Porter Neuroscience Research Center

Live NIH Videocast (archived after seminar)

BRAIN Initiative as “Moonshot”

NIH director Francis Collins, M.D., discusses some of the 58 projects funded in the first wave of grants awarded by the NIH under the BRAIN Initiative. He spoke at a press conference announcing the awards, September 30, 2014.

Video published on October 2, 2014 by National Institute of Mental Health (NIMH)

Picturing the Brain – Paul Thompson

Dr. Paul Thompson talks about the work that he does at the Lab of Neuro Imaging (LONI) at UCLA.

He discusses brain health, the latest brain imaging technology and projects like ENIGMA, which involves a world-wide effort to create a brain database.

William Newsome and the BRAIN Initiative

Dr. William Newsome, co-chair of the NIH Science Advisory Committee, describes what the BRAIN Initiative is, why it is important, and how it can be achieved.

Newsome's talk was part of "Neuroscience Mini-symposium: From Perception to Decision", co-sponsored by NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai Key Laboratory of Brain Functional Genomics, and School of Psychology and Cognitive Science, East China Normal University.

Published on Jul 14, 2014 by NYU Shanghai Research

NIH Neuroscience Seminar- April 6, 2015

TITLE: Linking neuronal activity and gene expression: Ca nanodomains and long-range signaling

AUTHOR: Richard Tsien, D.Phil., NYU Neuroscience Institute

TIME: 12:00:00 PM DATE: Monday, March 23, 2015

PLACE: Porter Neuroscience Research Center

Live NIH Videocast (archived after seminar)

NIH Neuroscience Seminar- March 30, 2015

TITLE: Membrane fusion mediated by SNARE proteins

AUTHOR: Reinhard Jahn, Ph.D., Max Planck Institute for Biophysical Chemistry

TIME: 12:00:00 PM DATE: Monday, March 23, 2015

PLACE: Porter Neuroscience Research Center

Live NIH Videocast (archived after seminar)

NIH Neuroscience Seminar- March 23, 2015

TITLE: Learning to Predict: Studies of Neural Circuits in Fish and Flies

AUTHOR: Larry Abbott, Ph.D., Columbia University

TIME: , 12:00:00 PM DATE: Monday, March 16, 2015

PLACE: Porter Neuroscience Research Center

HOST: Bruno Averbeck

NIH Neuroscience Seminar – Feb. 11, 2013

TITLE: Regulation of glutamate receptors and synaptic plasticity in the brain

AUTHOR: Richard Huganir, Ph.D., University of California, Berkeley

TIME: 12:00:00 PM DATE: Monday, Feb 11, 2013

Archived NIH Videocast

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