PLOS has four open access journals that address, with varying focus, neuroscience research: PLOS Biology, PLOS Computational Biology, PLOS Medicine, and PLOS ONE.

PLOS also has a Neuroscience Collection of research organized in two broad categories: Cognitive Neuroscience and Brain Mapping Methods and a blog with neuroscience related posts including contributors commenting on the SfN conferences called PLOS Neuro.