Models capturing hippocampal neuronal behaviors

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A model of CA1 O-LM neuron, which exhibits rebound behavior and undergoes Andronov Hopf bifurcation.

Summary

Poster Title: Computationally efficient models capturing diverse hippocampal neuronal behaviors

Authors: Siva Venkadesh, Alexander O. Komendantov, David J. Hamilton, Diek W. Wheeler, Stanislav Listopad2, Jeffrey L. Krichmar3, Giorgio A. Ascoli1

Hippocampome.org is a knowledge base of neuron types in the rodent hippocampal formation upon which we aim to build a full-scale model of the hippocampus. Simulation costs of biophysically detailed Hodgkin-Huxley-type neuronal models often impose limits on the scale of biologically realistic network models. Therefore, our immediate modeling goal is to create computationally efficient models that quantitatively reproduce various firing-pattern features of hippocampal neuron types.

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