Principal Investigator: Joseph R Ecker
Salk Institute for Biological Studies
Being able to study the epigenome in great detail and in its entirety will provide a better understanding of plant productivity and stress resistance, the dynamics of the human genome, stem cells’ capacity to self-renew and how epigenetic factors contribute to the development of tumors and disease. We are now exploring how DNA methylation effects the development of human embryonic stem (hES) cells as well as induced pluripotent stem (IPS) cells as they are induced to differentiate into other types of cells.
Web Information
Website: pbio.salk.edu/pbioe/members
Brain Initiative Grant
Contact Information
Phone: (858) 453-4100 x1752
Address: Salk Institute Genomic Analysis Laboratory
10010 N. Torrey Pines Road La Jolla, CA 92037
Research
The development of DNA sequencing technologies that produce vast amounts of sequence information has triggered a paradigm shift in biology, enabling massively parallel surveying of complex nucleic acid populations. The diversity of applications to which these technologies have already been applied demonstrates the immense range of cellular processes and properties that can now be studied at the single-base resolution. These applications include, but are not limited to, the sequencing of genomes to uncover nucleotide polymorphisms and structural variation, as well as epigenomes to reveal sites of DNA–protein interaction and ...
