Schnitzer Group – Stanford

Principal Investigator: Mark J Schnitzer Stanford Neurosciencs Institute

The Schnitzer Group has three major research efforts: Development and application of fiber-optic, micro-optic, and nanophotonic imaging techniques for studies of learning and memory in behaving mice and for clinical uses in humans; In vivo fluorescence imaging and behavioral studies of hippocampal-dependent cognition and learning; and Development of high-throughput, massively parallel imaging techniques for studying brain function in large numbers of Drosophila concurrently.

 

Web Information

Website:  http://pyramidal.stanford.edu/index.html Brain Initiative Grant

Contact Information

Email: schnizerlab@gmail.com Address: James H. Clark Center – Room W080 318 Campus Drive Stanford, CA 94305

Research

Dr. Schnitzer has longstanding interests in neural circuit dynamics and optical imaging, and his laboratory has three major research efforts:

In vivo fluorescence imaging and behavioral studies of cerebellar-dependent motor control and motor learning. Development and application of fiber-optic fluorescence microendoscopy imaging techniques for studies of learning and memory in behaving mice and for clinical uses in humans. Development of high-throughput, massively parallel imaging techniques for studying brain function in large numbers of Drosophila concurrently.

The long-term goal of our research is to advance experimental paradigms for understanding normal cognitive and disease processes at the level of neural circuits, with emphasis on learning and memory processes. By contrast, much current research on learning and memory concentrates on ...

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Laboratory of Neural Circuit Dynamics – Zurich

To study neural circuit function our research is focused on advancing and applying in vivo high-resolution imaging methods, with a particular emphasis on neocortical microcircuitry. The lab's specific goals are to reveal principles of single-cell and local network computation and to decipher the neural codes governing information processing as well as circuit plasticity.

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Xu Research Group – Cornell

Principal Investigator, Chris Xu Cornell University

Xu Research Group has two main thrusts: biomedical imaging and fiber optics. The Group is exploring new concepts and techniques for in vivo imaging deep into scattering biological specimens, such as mouse brain; developing new medical endoscopes for non-invasive real-time diagnostics of tissues without any exogenous contrast agent and novel optical fibers and fiber-based devices for biomedical imaging and optical communications.

Nonlinear Optics in Higher-order-mode Fibers. Xu Research Group

Web Information

Website:  http://xu.research.engineering.cornell.edu/ Brain Initiative Grant

Contact Information

EmailCX10@cornell.edu Phone: 607 255-1460 Address: 276 Clark Hall:

Research

    Our research has two main thrusts: biomedical imaging and fiber optics. We are exploring new concepts and techniques for in vivo imaging deep into scattering biological specimens, such as mouse brain. We are developing new medical endoscopes for non-invasive real-time diagnostics of tissues without any exogenous contrast agent. We are developing novel optical fibers and fiber-based devices for biomedical imaging and optical communications.

Biomedical Imaging

Deep Imaging in Scattering Biological Tissue Laser scanning multiphoton microscopy (MPM) has greatly improved the penetration depth of optical imaging and is proven to be well suited for a variety of imaging applications deep within intact or semi-intact tissues. Nonetheless, MPM ...

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Kramer Lab – Stanford

Principal Investigator: Richard  Kramer UC Berkeley Helen Wills Neuroscience Institute

Kramer Lab studies utilize novel chemical reagents to modify the function of ion channels and synapses.  This Chemical-Biological approach is designed to allow non-invasive optical sensing and optical manipulation of channels and synapses in the nervous system. One major goal of this research is to develop the technology for restoring vision in degenerative blinding diseases.

Regulating native ion channels with light – we have sought a simple method for bestowing light-sensitivity onto neurons that does not require exogenous gene expression, but rather can be carried out on freshly obtained, relatively unadulterated, neural tissue.

Web Information

Website:  mcb.berkeley.edu/labs/kramer/ Brain Initiative Grant

Contact Information

Email: rhkramer@berkeley.edu Phone: (510) 643-2406 Address: University of California Department of Molecular and Cell Biology 121 Life Sciences Addition Berkeley, CA 94720-3200

Research

Nerve cells communicate using electrical and chemical signals. Ion channels are the proteins that generate electrical signals in neurons, and synaptic transmission is the process that allows a neuron to communicate chemically with other cells.  Our studies utilize novel chemical reagents to modify the function of ion channels and synapses.  This Chemical-Biological approach is designed to allow non-invasive optical sensing and optical manipulation of channels and synapses in the nervous system. One major goal of ...

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John B. Pierce Laboratory – Yale

The John B. Pierce Laboratory is a nonprofit, independent research institute that is formally affiliated with Yale University. The Laboratory has a long and distinguished history as a leading center for the study of physiological regulatory systems such as those that maintain body temperature, respiration, body fluids, and metabolism within healthy limits.

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Nedivi Lab – MIT

Plasticity is a prominent feature of brain development, and in the adult underlies learning and memory and adaptive reorganization of sensory maps. The Nedivi lab, part of the Picower Institute for Learning and Memory, studies the cellular mechanisms that underlie activity-dependent plasticity in the developing and adult brain through studies of neuronal structural dynamics, identification of the participating genes, and characterization of the proteins they encode.

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