TITLE: Mechanisms of ubiquitin signaling in gene regulation and chromatin dynamics
AUTHOR: Cynthia Wolberger, Ph.D., Johns Hopkins University
TIME: 12:00:00 PM DATE: Monday, April 13, 2015
PLACE: Porter Neuroscience Research Center
Live NIH Videocast (archived after seminar)
Profile
Professor of Biophysics and Biophysical Chemistry, School of Medicine
Principal Investigator, Wolberger Lab
Cynthia Wolberger is interested in the structural and mechanistic basis for transcriptional regulation and ubiquitin signaling.Her lab focuses on molecular basis for these events, which ensure the integrity and expression of the genome. We use x-ray crystallography, enzymology, cell-based assays and a variety of biophysical tools to gain insights into the mechanisms underlying these essential cellular processes.
Web Information
Wolberger Webpage: http://pmcb.jhu.edu/faculty/wolberger-profile.html
Research Overview
One of the key ways in which cells dynamically regulate protein function is through reversible post-translational modifications. Lysine residues in particular are subject to a remarkably diverse array of modifications. Our research centers on two types of lysine modification, ubiquitination and acetylation, which play critical role in regulating transcription, the response to DNA damage and intracellular signaling. We use a wide array of approaches including x-ray crystallography, small-angle x-ray scattering, biophysical studies of binding interactions, enzymology and cell-based studies to tackle biological questions.
The attachment of the small protein, ubiquitin, to lysine residues serves a wide variety of signaling functions. In addition to its ...
