Gerry Rubin, the executive director of the Howard Hughes Medical Institute’s Janelia Farm Research Campus discusses why the leading edge research institution chose Loudoun Virginia for their $500 million + project. Blue sky thinking, creativity and highly educated workforce.

Produced by Loudoun County Virginia Government. Published July 28, 2010

https://www.youtube.com/watch?v=FpE9hFJWA8k

“The fruit fly has a very long and distinguished career in science. At a facility considered a Nirvana for scientists, researchers pursue greater understanding of biomedical processes, using test subjects like dragonflies and zebrafish.

PBS News Hour Science correspondent Miles O’Brien reports on how the Janelia Farm Research Campus supports groundbreaking basic research.”

Article on PBS website art

Published July 23, 2014 by PBS Newshour

Transcript

GWEN IFILL: Next: trying to better understand what’s happening in the brain of a fruit fly, a dragonfly, or a zebra fish, all part of a larger puzzle to learn more about how our own brains work.

NewsHour science correspondent Miles O’Brien has the first in our three-part series on the science of the brain.

MILES O’BRIEN: Oh, to be a fly on the wall at the Basic Research Facility scientist consider nirvana. You might see a Nobel Prize in the making or you might be subjected to this, the fruit fly version of a scary movie, the rapidly growing shadow of a predator homing in for the kill.

GWYNETH CARD, Howard Hughes Medical Institute-Janelia Farm Research Campus: My lab is really interested in how flies make decisions.

MILES O’BRIEN: Neuroscientist Gwyneth Card runs a laboratory at the Howard Hughes Medical ...

YouTube link

“New computer software to unravel embryonic development cell by cell”

Researchers at the Howard Hughes Medical Institute Janelia Research campus are using a new type of computer software to track and image how a nervous system develops in unprecedented detail. The new system is able to track individual cells during embryonic development, giving scientists a powerful to tool to create a blueprint of how brains form. Ben Gruber reports, Reuters.

Published Aug. 6, 2014 by Reuters

Nobel Laureate in Chemistry 2014: Eric Betzig, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

From: The Nobel Lectures 2014, 2014-12-08.

Published on Jan. 8, 2015 by Vetenskapsakademien

In this lecture, held on 3/9/15 at UC Berkeley, Nobel Laureate Eric Betzig, describes three areas focused on addressing the challenges of high resolution imaging: super-resolution microscopy; plane illumination microscopy using non-diffracting beams; and adaptive optics to recover optimal images from within optically heterogeneous specimens.

Published on March 15, 2015 by UC Berkeley Events

During their 20-year friendship, Eric Betzig and Harald Hess, now at Janelia Farm/HHMI, worked together and separately, in academia and industry, before eventually joining forces to develop the first super-high-resolution PALM microscope.

They tell us the story of this journey and emphasize how their unusual and varied backgrounds provided the skills to complete the project.

Uploaded on Jan. 8, 2011 by iBioMagazine

https://www.youtube.com/watch?v=esC6cr6qfs8Video can’t be loaded because JavaScript is disabled: Resolving Everything (https://www.youtube.com/watch?v=esC6cr6qfs8)

Harald Hess of the Janelia Research Campus of the Howard Hughes Medical Institute describes his path in basic physics, industry and biology and how the challenge of resolution in microscopy has guided and inspired his research.

Published April 1, 2015 by the National High Magnetic Field Laboratory

“An Exploration of Brain Dynamics”

Get a behind-the-scenes look at a day in the lab of neuroscientist Karel Svoboda as his group at the Howard Hughes Medical Institute’s Janelia Research Campus pushes to build a new type of microscope and uses a virtual reality system to learn how mice explore the world.

Published on July 28, 2014 by zincfinger23

“A platform for large-scale neuroscience” Jeremy Freeman (HHMI Janelia Farm Research Campus)

Filmed and recorded live at Spark Summit 2014 in San Francisco at the Westin St. Francis.

Published on July 17, 2014 by Apache Spark

“Tools for studying neurons, the only important cells in the brain” from the Glia in Health & Disease 7/19/2014

Presented by Dr. Loren Looger, HHMI Janelia Farm Part of Cold Springs Harbor Laboratory Keynote lecture series

Pulbished on July 21, 2014 by  CSHL Leading Strand

Gary Marcus, a cognitive scientist at New York University, is the author of four books. He also writes a blog on artificial intelligence and science for The New Yorker. Paul G. Allen and his sister Jody Allen founded the Allen Institute for Brain Science.

A true visionary, Paul Allen was inspired by a host of leading scientists 10 years ago to move the needle on brain research.

Published on October 3, 2013  by Allen Institute for Brain Science

The twelve videos in this post are tutorials on the various Allen Brain Atlases published between 2011 and 2015.

Tutorial: Allen Human Brain Atlas

“This tutorial provides a brief orientation to the data and basic features of the Allen Human Brain Atlas, a multi-modal atlas of gene expression in the adult human brain.”

Allen Cell Types Database: Understanding the fundamental building blocks of the brain

“The Allen Institute for Brain Science is taking the first major scientific step to create a searchable standards database for the brain with the launch of the Allen Cell Types Database.”

“Allen Cell Types Database: Understanding the fundamental building blocks of the brain”

The Allen Institute for Brain Science is taking the first major scientific step to create a searchable standards database for the brain with the launch of the Allen Cell Types Database.

Published on May 14, 2015 by Allen Institute for Brain Science

A virtual journey through the Allen Institute for Brain Science’s Electron Microscopy (EM) imaging program

Published on April 9, 2014 by Allen Institute for Brain Science

“This movie displays 21 mapping experiments from the Allen Mouse Brain Connectivity Atlas: a tool to investigate how different regions of the brain are connected. The density of axons at each voxel (dot) are displayed as overlapping circles color-coded by the area of the brain from which the axons are projecting. This animation shows how projections from different regions of the cortex divide the thalamus and striatum into distinct domains. The Allen Mouse Brain Connectivity Atlas is available to everyone online at www.brain-map.org.“

Published on April 9, 2014 by Allen Institute for Brain Science

“This video shows a composite of 80 injection sites of a viral tracer in the cortex (round spheres) and their major projections into the thalamus. We can clearly see that the spatial pattern of the injections is conserved in the thalamus. This kind of information was only previously available in piecemeal form, but with the comprehensive, standardized data in the Allen Mouse Brain Connectivity Atlas, we can reproducibly measure and visualize this topography.”

Published on February 27, 2014 by Allen Institute for Brain Science

“Brain mapping and integrating multimodal data across subjects and projects.”

Dr. Arthur Toga is Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering at the University of Southern California, and serves as the inaugural Director of the USC Institute for Neuroimaging and Informatics. He also holds an appointment in the USC Viterbi School of Engineering. A leading authority on neuroimaging, informatics, mapping brain structure and function, and brain atlasing, Dr. Toga is the former Distinguished Professor of Neurology, University Professor, Vice Chair of the Department of Neurology, Associate Dean at the Geffen School of Medicine, and Co-Director of the UCLA Brain Mapping Center.

Published on October 3, 2013  by Allen Institute for Brain Science

Published on November 12, 2012  by Allen Institute for Brain Science

Dr. Cori Bargmann, recent winner of the Kavli Prize in Neuroscience and a pioneer in methods of looking at C. elegans to uncover how neural circuits operate, presented the idea that particular classes of genes — neuropeptides to be specific — are good places to look for the genetic origin of behavior. Because much of the genome is conserved across species and throughout time, new behaviors may be created by redeploying old genes in different ways.

Uncovering the basic building blocks of behavior, she believes, is an unsolved question in neuroscience that is now becoming solvable.

“The question is not whether calbindin is expressed in the hippocampus, but whether it has something to do with the unique functions of human memory capabilities,” Bargmann said. “That is a hard question.” Certain kinds of molecules relate to innate behaviors that are shared across ...

Published on October 12, 2012  by Allen Institute for Brain Science

“Brain rhythms and cognition”

From physics to electrophysiology and imaging, Dr. Miller and his lab focus on broad and far-reaching approaches to neuroscience questions. This symposium talk focused on questions similarly posed by Sabine Kastner, namely the relationship between action potential timing and brain function. By recording neural activity in monkeys as they switch among two tasks, Miller found that over half of the recording sites in the network for one task also appear to participate in the network for the other task. This suggests that circuitry in the prefrontal cortex may overlap and that oscillations are the key to selecting appropriate networks for the task that needs to be performed. Miller showed that neural ensembles, or networks, in close proximity oscillate out of phase with one another to avoid being simultaneously activated. That is, the oscillations bind neural ensembles ...

“Deciphering the mammalian brain transcriptome”

Published on November 12, 2012  by Allen Institute for Brain Science

The development, structure and function of our brains are guided by selective usage of the 20,000-odd genes in our genomes. Taking advantage of the Allen Institute’s anatomically and genomically comprehensive atlases of gene expression in the developing brain in species from mouse to human, Dr. Lein explores the molecular logic of gene expression in the brain. How do gene expression profiles relate to the functional and cellular architecture of the brain, and what makes the human brain unique? Focusing on the human neocortex, the outermost layer of the brain, Lein showed that molecular similarities reflect spatial proximity across the neocortex; such that neighboring cortical regions are more similar to one another than to more distant regions. Surprisingly, these molecular similarities vary across the cortex in a graded fashion, in contrast to models of cortical architecture ...

“Neurotechnology: Fixing broken brains by decoding cortex”

Dr. Donoghue’s lab works in both basic and applied neuroscience, studying network computation on one end, and restoring lost motor cortical function on the other end. His work has culminated in BrainGate, a human brain-computer interface that senses neural activity in the motor cortex and decodes it to instruct a robotic arm or a cursor, reconnecting the cortex to lost action in the case of spinal cord injury or paralyzing disease such as amyotrophic lateral sclerosis. Donoghue showed video clips from his lab featuring long-paralyzed patients successfully navigating a robotic arm to drink their favorite beverage or guiding a computer cursor to communicate with loved ones. Among other noteworthy aspects of this work are the two notions that 1) the program actually decodes activity in the motor cortex rather than using a binary measure of activity (e.g., on or off) and 2) individual neurons in the motor cortex retain activity and function, even in quadriplegics who have not used this area of the brain in over a dozen years. While the functional utility of this work is self-evident, the value and applications to basic neuroscience are no less important. In going from a plan ...

Visualizing the activity and anatomy of brain circuits: optogenetic sensors and tissue clearing approaches

Published on September 26, 2014 by Allen Institute for Brain Science

Day one videocast: Morning sessions included 3D printed Eyewire neurons by James Drake and Oculus fly through the brain.

Afternoon seesions included strategies for how to implement open source bio printing accessible and inexpensive… available for research. NIH 3D printer exchange is creating file formats for bioprinting cell types.

About the Festival

The NIAID Office of Cyber Infrastructure and Computational Biology (OCICB) is pleased to host our annual 2015 Bioinformatics & Computational Biosciences Festival, Science in 3D.

Despite the fast-growing applications for 3D technologies, they are not widely used in the biosciences at present. The festival will look at several aspects of 3D technologies including modeling, printing, and visualization. Speakers will explore bioprinting, physician and patient education, medical and surgical devices, augmented reality for medicine, and policies surrounding this exploding field. The festival will feature high-level presentations by subject matter experts from government agencies, academia, and the private sector.

Day one videocast   Day two videocast

Morning sessions included 3D printed Eyewire neurons by James Drake

and Oculus fly through the brain. See below from TED 2014 video.

Fueling Discovery: BrainSpan Atlas of the Developing Human Brain

“Ed Lein, an investigator at the Allen Institute for Brain Science, discusses how we are creating the BrainSpan Atlas of the Developing Human Brain and learning about how genes are used differently in the developing brain.”

Published on April 9, 2014 by Allen Institute for Brain Science

“Mice, bugs and hamsters are no longer the only way to study the brain. Functional MRI (fMRI) allows scientists to map brain activity in living, breathing, decision-making human beings. Read Montague gives an overview of how this technology is helping us understand the complicated ways in which we interact with each other.”

Filmed June 2012 at TED Global 2012 Uploaded to YouTube on September 24, 2012 by TED 

“Every morning we wake up and regain consciousness — that is a marvelous fact — but what exactly is it that we regain? Neuroscientist Antonio Damasio uses this simple question to give us a glimpse into how our brains create our sense of self.”

Filmed March 2011 at TED 2011 Uploaded to YouTube on December 18, 2011 by TED 

TED Talks webpage

“How do you remember where you parked your car? How do you know if you’re moving in the right direction? Neuroscientist Neil Burgess studies the neural mechanisms that map the space around us, and how they link to memory and imagination.”

Filmed November 20111 at TEDSalon London 2011 Uploaded to YouTube on February 6, 2012 by TED 

TED Talks webpage

“How do you remember where you parked your car? How do you know if you’re moving in the right direction? Neuroscientist Neil Burgess studies the neural mechanisms that map the space around us, and how they link to memory and imagination.”

Filmed November 20111 at TEDSalon London 2011 Uploaded to YouTube on February 6, 2012 by TED 

TED Talks webpage

“The human brain is puzzling — it is curiously large given the size of our bodies, uses a tremendous amount of energy for its weight and has a bizarrely dense cerebral cortex. But: why? Neuroscientist Suzana Herculano-Houzel puts on her detective’s cap and leads us through this mystery. By making “brain soup,” she arrives at a startling conclusion.”

Filmed June 2013 at TEDGlobal 2013 Uploaded to YouTube on November 26, 2013 by TED 

TED Talks webpage

“As an expert on cutting-edge digital displays, Mary Lou Jepsen studies how to show our most creative ideas on screens. And as a brain surgery patient herself, she is driven to know more about the neural activity that underlies invention, creativity, thought. She meshes these two passions in a rather mind-blowing talk on two cutting-edge brain studies that might point to a new frontier in understanding how (and what) we think.”

Filmed March 2013 at TED 2013 Uploaded to YouTube on March 3, 2013 by TED 

TED Talks webpage

Despite intense interest in the ways brains work, we still have quite a rudimentary understanding of this organ, especially compared to our knowledge of the other organ systems in the body.

One central problem is that brain function is based on a much more complicated cellular organization than found in any other part of the body.

Published July 13, 2013 by Harvard University

Synopsis

Despite intense interest in the ways brains work, we still have quite a rudimentary understanding of this organ, especially compared to our knowledge of the other organ systems in the body. One central problem is that brain function is based on a much more complicated cellular organization than found in any other part of the body. The brain contains billions of nerve cells and these are interconnected by trillions of synapses in a vast wiring diagram. This wiring diagram has ...

“Vilayanur Ramachandran tells us what brain damage can reveal about the connection between celebral tissue and the mind, using three startling delusions as examples.”

Filmed march 2007 at TED 2007 Uploaded to YouTube on October 23, 2007 by TED  

TED Talks webpage

https://www.youtube.com/watch?v=igDuigbb-9I

“Understanding the Mind by Mapping the Brain”

Jacopo Annese, Director of the Brain Observatory at the University of California, San Diego is on a quest to collect, dissect, and digitize images of the human brain for the Digital Brain Library, which was launched with support from the National Science Foundation. Annese and his team look for connections, mapping brain structure and connecting it to human behavior.

NSF BRAIN Initiative Science Nation – August 4, 2011

Description

Neuroanatomist Jacopo Annese is looking for 1,000 brains. The Director of the Brain Observatory at the University of California, San Diego is on a quest to collect, dissect, and digitize images of the human brain for the Digital Brain Library, which was launched with support from the National Science Foundation. Annese and his team look for connections, mapping brain structure and connecting it to human behavior. He believes that with a large enough catalog of brains preserved as virtual models, scientists can explore the organ in ways unheard of, revealing new insights into what makes the brain tick. Annese is collecting data on the lives of the people who have already donated brains. He is also studying the behavior of people ...

The mapping of the mouse brain is giving researchers like Partha Mitra a better understanding of how neurons are connected and how they communicate across the regions of the brain.

NSF BRAIN Initiative Published APRIL 2, 2014

Dr. Paul Thompson talks about the work that he does at the Lab of Neuro Imaging (LONI) at UCLA.

He discusses brain health, the latest brain imaging technology and projects like ENIGMA, which involves a world-wide effort to create a brain database.

Published on July 13m 2013 by NIBIBgov