Neuroscience @Penn is based in the Department of Neuroscience with substantial coordination via the Mahoney Institute of Neuroscience.

Affiliated groups include: Behavioral Neuroscience at Penn, ; Center for Study of Addiction; Center for Cognitive Neuroscience, Center for Neuroscience and Society, Center for Sleep and Respiratory Neurobiology, Penn Medicine Neuroscience Center, Department of Neurology, Institute for Research in Cognitive Science, Penn Vision Research Center, Computational Neuroscience at Penn, and Neuroscience Graduate Group (NGG).