Yang Lab’s research is focused on applying comprehensive molecular and genetic approaches to study the pathogenesis of Huntington’s disease (HD) and Parkinson’s disease (PD), as well as exploring the molecular genetics and circuitry of the basal ganglia (BG), a brain region targeted in various neurodegenerative and neuropsychiatric disorders. The overarching approach of our lab is to develop genetic mouse models of these diseases, or create mice that carry mutations in the genes.